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Table 1

From: O313 Relation between adverse effects of ARV treatment and underlying risk in number needed to treat to harm (NNTH) – myocardial infarction and abacavir use

Change in factors contributing to underlying risk

Underlying risk of MI in 5 years (%)

NNTH

Example low risk profile (described in text)

0.1

1111

If total cholesterol 240 mg/dL (6.2 mmol/L)

0.2

555

If diabetes

0.2

555

If ECG-LVH

0.2

555

If sBP 160 mmHg

0.3

370

If HDL 35 mg/dL (0.9 mmol/L)

0.3

370

If smoking

0.4

277

If HDL and total cholesterol unfavourable

0.8

138

If smoking and diabetes

1.1

101

If smoking and total cholesterol unfavourable

1.0

111

If smoking and sBP 160 mmHg

1.3

85

If smoking and HDL unfavourable

1.6

69

If smoking and lipids unfavourable

3.1

35

If all unfavourable combined (excluding ECG-LVH)

10.1

11

If all unfavourable combined (including ECG-LVH)

15.0

7