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Table 2 Infant outcomes according to maternal antiretroviral regimens and duration of treatment in pregnancy

From: Birth outcomes in South African women receiving highly active antiretroviral therapy: a retrospective observational study

Variables

Early HAART-exposed

P

Late HAART-exposed

P

 

PI-based HAART

NVP-based HAART

EFV-based HAART

 

PI-based HAART

NVP-based HAART

EFV-based HAART

 

Birth weight (kg): n (%)

N = 135

N = 158

N = 95

 

N = 284

N = 103

N = 20

 

mean (SD)

3.0 (0.6)

2.9 (0.5)

2.7 (0.6)

0.002

2.9 (0.5)

2.9 (0.5)

2.8 (0.5)

0.59

0.75-1.49

5 (4)

0 (0)

3 (3)

 

2 (1)

0 (0)

0 (0)

 

1.5-2.49

18 (13)

31 (20)

33 (35)

 

46 (16)

23 (22)

5 (25)

 

>2.5

112 (83)

127 (80)

59 (62)

<0.001

236 (83)

80 (78)

15 (75)

0.50

Gestation: n (%)

N = 131

N = 167

N = 91

 

N = 290

N = 116

N = 21

 

extremely premature (<34 weeks)

13 (10)

15 (9)

12 (13)

 

0 (0)

3 (3)

0 (0)

 

preterm (34-36 weeks)

6 (5)

25 (15)

10 (11)

 

9 (3)

8 (7)

1 (5)

 

term/postdates (>36 weeks)

112 (86)

127 (76)

69 (76)

0.048

281 (97)

105 (91)

20 (95)

0.024

Birth weight - gestation n (%)

N = 123

N = 128

N = 61

 

N = 280

N = 101

N = 19

 

AGA

83 (67)

110 (86)

39 (64)

 

153 (55)

79 (78)

13 (61)

 

SGA

26 (21)

13 (10)

18 (30)

 

121 (43)

20 (20)

6 (32)

0.001

LGA

14 (11)

5 (4)

4 (7)

0.001

6 (2)

2 (2)

0 (0)

 

Infant HIV status: n (%)

N = 106

N = 156

N = 88

 

N = 214

N = 87

N = 15

 

HIV PCR positive

1 (1)

6 (4)

1 (1)

0.22

17 (8)

13 (15)

1 (7)

0.17

  1. HAART - highly active antiretroviral treatment; early HAART - HAART initiation <28 weeks of pregnancy; late HAART - HAART initiation at ≥28 weeks of pregnancy; PI - protease inhibitor, NVP - nevirapine; EFV - efavirenz; SD - standard deviation; SGA - small for gestational age; AGA - appropriate for gestational age; LGA - large for gestational age; PCR - polymerase chain reaction