Volume 11 Supplement 1

Abstracts of the Ninth International Congress on Drug Therapy in HIV Infection

Open Access

Impact of fasting bloods on hypertriglyceridemia

  • NA Billing1,
  • GJ Moyle1 and
  • M Nelson1
Journal of the International AIDS Society200811(Suppl 1):P98

DOI: 10.1186/1758-2652-11-S1-P98

Published: 10 November 2008

Purpose of the study

Abnormalities of lipid metabolism are common in HIV-infected patients and are accentuated in those receiving antiretroviral therapy, particularly with ritonavir. The measurement of non-fasting triglyceride levels is not currently common place as no standard values have been developed. The purpose of this study is to identify whether routine non-fasting bloods obtained in clinic are representative of lipid levels when compared to fasting levels.

Methods

Patients identified as having triglyceride levels above 3.0 mmol//I were requested to return for fasted sampling prior to consideration for potential intervention.

Summary of results

• 34 patients with elevated triglyceride levels were included

• All were males with a mean age of 47(± 8.6) years

See Table 1.
Table 1

Results of lipid levels when fasted.

Biochemical marker

n of group

Mean routine lipid levels (mmol/l)

Mean percentage reduction with fasted bloods

95% CI

Cholesterol

34

6.04(± 1.2)

-4.6%

-10.27%, 1.00%

HDL:Cholesterol ratio

11

7.11(± 1.92)

-35.4%

-56.27%, -14.57%

Triglyceride level

34

5.29(± 2.9)

-29.5%

-41.33%, -17.64%

76% of patients had a reduction in their triglyceride levels with repeated fasting. 81% of patients had a reduction in their HDL:Cholesterol ratio when bloods were repeated fasting. Both these results were statistically significant at a confidence interval of 95%.

Conclusion

All individuals should routinely have their bloods taken in the fasting state. Failure to do so may result in the inappropriate initiation of lipid-lowering agents or potential treatment changes.

Authors’ Affiliations

(1)
Chelsea and Westminster Hospital

Copyright

© Billing et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

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