cART in vertically HIV-infected children treated since infancy

Purpose of the study

To evaluate cART efficacy, number of regimens and resistance development in vertically HIV-infected children treated since infancy.

Methods

27 children vertically infected with HIV. In 6/27 children treatment was started before HAART era. In 11/27 patients cART regimen was based on baseline resistance reports. Additionally, in eight children resistance tests were performed before therapy changing. (Table 1.)

Table 1 cART efficacy

Summary of Results

6/27 (22%) children have been receiving their first regimen (the length of treatment: 10 months – 4.5 years). 21/27 (78%) patients have changed their therapies, including 12/21 (57%) with treatment failure.

Conclusions

cART in vertically HIV-infected children treated since infancy is effective. Most of the patients had to change their regimens because of treatment failure or adverse events. Multidrug resistance (double or triple class) appeared in 15% of patients.